Tumor-associated antigens and development of immunotherapeutics strategies
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چکیده
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Novel treatment strategies for cancer and their tumor-targeting approaches using antibodies against tumor-associated antigens.
Novel treatment strategies for cancer that are based on a more detailed understanding over the tumor biology are based on the latest new technology and are expected to improve the current treatment outcome for patients with cancer. However, many of these strategies still have one common and critical problem, being their limited specificity for tumor cells. In this context, antibodies against tu...
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15 صفحه اولSynthetic tumor-associated glycopeptide antigens.
Glycopeptides with TN antigen (GalNAc)Ser/Thr and T-antigen structures (beta Gall-3GalNAc)Ser/Thr, described as tumor-associated antigens, were synthesized and coupled to bovine serum albumin. Alternatively, synthetic methods for the construction of beta-anomeric analogues of the TN and T-antigen glycopeptides were developed, aiming at antigenic structures having a varied stereochemistry of the...
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Design and in Silico Construction of New Efficient Antibodies Against Gastric Tumor-associated Antigens Towards Introducing Combined Strategy for Vaccine Tumor Therapy
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ژورنال
عنوان ژورنال: Biopolymers and Cell
سال: 2005
ISSN: 0233-7657,1993-6842
DOI: 10.7124/bc.0006ec